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Description
Protein Homeostasis Dysregulation Under pathological conditions, syn, a natively unfolded presynaptic protein, misfolds and aberrantly aggregates into toxic oligomeric and fibrillar species
Keap1 -null animals show postnatal lethality due to hyperactivation of Nrf2, which results in aberrant proliferation of keratinocytes in the esophagus and forestomach (171)
To increase aqueous solubility of the compounds to facilitate structural studies, the cycloheptyl substituent in TGR uncompetitive inhibitor 8 was replaced with a sugar moiety, resulting in compound 9 , a noncompetitive inhibitor and thus capable of binding the enzyme in absence of NADPH
The antioxidant responsive element
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Understanding cachexia as a cancer metabolism syndrome
