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In a longitudinal study, regional FDG-PET brain changes were analyzed in 25 iRBD patients at baseline, and after 2 and 4 years

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Studies have shown that high concentrations of AuNPs can impair the activity of chondrocytes [358], while low concentrations of AuNPs have anti-inflammatory properties and can reduce the expression of inflammatory markers such as IL-1, TNF-, COX-2, and NF-B in cell cultures and animal models [359]