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Epub 03/02/2015
The incidence of mammary gland carcinoma in male rats increased in animals treated with 10 mg/kg/day (3 times the MRHD based on AUC)
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[DOI] [PubMed] [Google Scholar] Li Y, Heng J, Sun D, Zhang B, Zhang X, Zheng Y, Shi WW, Wang TY, Li JY, Sun X, et al
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Folate-rich diet increased DNA methylation of genes such as p16 [114] in mouse colon and protooncogenes such as PDGF-B (platelet-derived growth factor-B), Ras (rat sarcoma), and survivin in a mouse model of gliomagenesis [115]
