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doi:10.2340/000155555577460462 2019 The Author(s)

Circulation Cardiovascular quality and outcomes

The first significant HCV epidemic in Portugal occurred between 1930s and 1960s, was caused almost exclusively by GT1b and was likely associated with blood transfusions

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The effect of aged garlic extract on the atherosclerotic process - a randomized double-blind placebo-controlled trial

The reason is that only one nucleotide substitution is needed relative to the subtype 1a sequence to generate this variant, whereas two substitutions are needed relative to the 1b sequence (codon usage bias)