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S., Cao, H., Hall, A

These may act as signaling metabolites with anti-tumor effects by engaging G-protein receptors and inhibiting class-I histone deacetylases, altering gene expression, and dampening PI3KAKT-mTOR signaling 354,355

Studies have shown that copper ion levels in mesothelioma affect the infiltration of CD4+ T cells, with an increase in CD4+ T cells when copper ion concentration significantly decreases, but the infiltration level of CD8+ T cells is not affected (118)
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Peroxiredoxin involvement in the initiation and progression of human cancer

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