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& Buvat, J

This is different from steroid hormones, which are lipid-based and can enter cells to influence gene expression more directly

During HBs specification, the pioneer factors recruit EZH2, a histone methyltransferase (KMTs) that catalyzes histone three lysine 27 (H3K27) me3, to silent pancreatic-specific genes in HBs (Tachmatzidi et al., 2021), which exerts unique functions in liver-specific gene activation by interacting and travelling with RNA polymerase II from the distal to proximal regions of transcription start sites (Horisawa et al., 2020)

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doi: 10.1016/j.tips.2013.01.001

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