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"Pfizer/BioNTech COVID-19 vaccine approved for young people in Switzerland" (Press release)

The strong protic base necessary to abstract the proton is a tertiary alkoxide that is generated from the hydroquinone form of vitamin K, through a mechanism involving the reaction with molecular oxygen, referred to as base strength amplification by oxidation [206]

pH control is important , NAD+ is stable at neutral pH (6.5 to 7.5)

N Engl J Med 371:313325 Gough SC, Bode B, Woo V et al (2014) Efficacy and safety of a fixed-ratio combination of insulin degludec and liraglutide (IDegLira) compared with its components given alone: results of a phase 3, open-label, randomised, 26-week, treat-to-target trial in insulin-naive patients with type 2 diabetes

APN is important in modulating the activity of several peptide hormones (Albiston et al., 2004, Luan and Xu, 2007)
