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With major catalysts like the oral semaglutide decision and higher-dose semaglutide filing expected by year-end, Novo Nordisk is building a powerful upward trajectory to carry it through 2026 and beyond

As a consequence, GDH flux (Figure 1, ) increases [5] supplying anaplerosis as malate exits the cycle forming pyruvate which in turn supports citrate formation (Figure 2)

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Furthermore, advanced research into ferroptosis mechanisms in CHD may identify novel targets and strategies for CHD prevention and treatment, potentially mitigating myocardial injury by inhibiting ferroptosis-related signaling pathways or enhancing antioxidant capacity, ultimately improving cardiac function and quality of life for CHD patients

Platt MP, Bolding KA, Wayne CR, Chaudhry S, Cutforth T, Franks KM, et al