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This study gives good in vivo evidence that IGFBP-4 proteolysis, which results in decreased IGF binding, promotes tumour growth

et al., Drug Design, Development and Therapy Bottom line: IGF-1 LR3 is not a hormone disruptor, and it carries very little risk of masculinizing effects

Ferulic acid exerts neuroprotective effects in a mouse model of PD by decreasing the levels of phospho-Akt, phospho-pyruvate dehydrogenase kinase-1, and phospho-Bad and increasing caspase-3 levels [107]

Cold Spring Harb Perspect Biol (2011) 3:a003293

It is synthesized by the decidua and measurable in maternal blood in early pregnancy

However, further studies are needed to confirm their efficacy and clarify whether their therapeutic effects are truly mediated through antioxidant mechanisms