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I think there must be less nerve damage with a smaller needle to, that would seem to make sense anyway

In addition to being used as a staining agent in medical imaging and surgery, methylene blue is FDA-approved as a first-line antidote for methemoglobinemia and used off-label in cases of cyanide poisoning, carbon monoxide toxicity, and certain drug-induced conditions

The latter arise from malabsorption from food-bound B12 induced by the hypochlorhydria associated with atrophic gastritis caused by the Helicobacter pylori, H pylori jnfection of the stomach (Sobczynska-Malefora et al., 2021)

Epithelia are tight tissues due exclusively to the presence of TJ that selectively regulate the paracellular flux of ions (see Role of Tight Junctions in Crucial Physiological Processes)

The duration and severity of hangover symptoms varies from person to person