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American family physician (2010) 6(2):10822

More recent clinical trials have found no difference in comparison to a placebo (Javed et al., 2015)

Metformin enhances autophagy, reduces cardiac hypertrophy, and shows promise for improving functional outcomes in heart failure

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However, the main active form of AFB1 is generally considered to be the AFB1 epoxide, which may attack oxygen and sulfur heteroatoms and nucleophilic nitrogen in cellular components