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Otra ocasin en que puede verse pigmentacin caf difusa ocurre en pacientes con cncer pulmonar (carcinoma broncognico), o infecciones pulmonares severas, en los cuales se observa pigmento melnico difuso en paladar blando

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It is characterized by deleterious alterations in the NF1 tumor suppressor gene at 17q11.2, resulting in heterozygous, loss-of-function mutations
