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Compounds like Mots-c or certain GLP-1 receptor agonists are sometimes considered

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Groups receiving Fragment 176-191 were reported to display modest reductions in body weight compared to controls, with some groups also showing trends toward improved cholesterol and glucose tolerance

The latter cluster contained exclusively 5A-1MQ-treated animals switched from WD to LD (the WD/LD-T group), representing ~ 60% of all WD/LD-T animals