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A synergic antineoplastic effect was observed when CQ was used in combination with radiotherapy on U87 glioma initiating cells (U87 GICs) with respect to either radiation or CQ treatment alone, through apoptosis induction and autophagy inhibition, promoting cell cycle arrest in the G 0 /G 1 phase, increasing the expression of caspase-3, and decreasing the expression of Bcl-2 and autophagosome formation [267]

A hallmark of NRF2-active tumors is metabolic reprogramming to promote glutamine metabolism, production of pentose phosphate pathway (PPP) intermediaries, and redox state effector proteins [77]

Future directions Dietary interventions for the treatment and prevention of diseases are now widely acknowledged and have increasingly gained importance

Somineni HK, Kugathasan S

One such supplement is StemEnhance

Other studies performed in China have suggested certain fruits and vegetables may be especially protective, finding higher intakes of cabbage, Chinese cabbage, broccoli, tomatoes, and carrots, as well as apples and kiwi fruits, were linked to lower fibroid risk (Zhou 2020