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reported higher salivary MDA and lower antioxidants, such as vitamins A/E, in erosive OLP patients, linking OS to lesion susceptibility (63)
This cooperative effect is most noticeable during cellular energy shifts, when ATP levels fall to 2mM, unfolding occurs in the regulatory domains ATP-binding pocket (D294-R301), this increases the overall conformational entropy of the protein and enhances the catalytic efficiency for scarce substrates ( Under pathological conditions, abnormal modifications of protein domains significantly disrupt their functional stability

Curcumin Pyrazole and its derivative (N-(3-Nitrophenylpyrazole) Curcumin inhibit aggregation, disrupt fibrils and modulate toxicity of Wild type and Mutant -Synuclein

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