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All in all, astrocytic responses in AD are complex and disease stage-specific: in the early, compensated phase of AD (manifested by mild cognitive impairment) astrocytes, together with other neuroglia become reactive and arguably protect brain tissue

N., Wagh, V., Shirakawa, J., & Kulkarni, R

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we observed a 11.7-fold change for venetoclax, a 18.4-fold change for AZD-5991, and an 5.5-fold change for ibrutinib

Therefore, DHODH has emerged as a potential regulatory hub, where its inhibition may enhance ferroptotic cell death, offering a novel angle for therapeutic intervention, particularly in cancers such as pancreatic adenocarcinoma (175) and breast cancer (176), where certain cells show resistance to other forms of cell death (171,177)