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While cortisone is highly effective at quickly reducing inflammation and pain, it can cause issues with long-term use, such as tissue atrophy, weakened tendons, and blood sugar elevation

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While a two-year clinical trial using 300 mg per day did not show major changes in nerve function, shorter studies lasting 3 to 12 weeks found that higher doses, up to 600 mg daily, improved symptoms in people with diabetic neuropathy

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