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Together, these data strongly support the hypothesis that SPTL-1 regulates SKN-1 activation via ceramide production in germline-deficient animals

Kidney Int 92(6):1526-35 2017 PMC5696089 Reardon CA, Lingaraju A, Schoenfelt KQ, Zhou G, Cui C, Jacobs-El H, Babenko I, Hoofnagle AN, Czyz D, Shuman H, Vaisar T, Becker L

10.1006/taap.1994.1042 Toxicol

Universidad del Zulia

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In these groups, therapy is potentially dangerous because of the increased likelihood of life-threatening infection
