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Their reactivity is based on the 1,3-dicarbonyl chemistry originally demonstrated with dimedone
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Clin Endocrinol 42:249254 Beshyah SA, Thomas E, Kyd P, Sharp P, Fairney A, Johnston DG (1994) The effect of growth hormone replacement therapy in hypopituitary adults on calcium and bone metabolism
Exposure to the treatment is associated with various challenges for CAR-T cells and BiTEs
Legris et al., 2016
Nicotinamide can also be hydrolyzed to nicotinic acid (NA) in the lumen of the small intestines and then absorbed
