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In view of the relationship between HCN channels and neuronal excitability in the modulation of cognitive function, the present study hypothesized that Iva could possess a therapeutic effect against Sco models of dementia, based on HCN blockage mechanisms in cerebral areas related to cognitive functions

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[DOI] [PMC free article] [PubMed] [Google Scholar] 33.Toda K, Nishikawa G, Iwamoto M, Itatani Y, Takahashi R, Sakai Y, et al

Kawas LH, McCoy AT, Yamamoto BJ, Wright JW, Harding JW

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Absorption is usually completed in 5 to 10 minutes of insertion before bowel movement feelings