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doi: 10.3389/fmed.2022.812967 Received 11 November 2021 Accepted 14 February 2022 Published 10 March 2022 Volume 9 - 2022 Edited by Tzvi Dwolatzky, Technion Israel Institute of Technology, Israel Reviewed by Zongwei Wang, Beth Israel Deaconess Medical Center and Harvard Medical School, United States

Currently, this class of linker has been employed in Mylotarg and several maytansine-based candidates in clinical trials

doi: 10.3177/jnsv.57.274

showed that the treatment with V-9302 in colorectal cancer (CRC) cell lines resulted in decreased mTOR activity, as assessed by investigating the expression of phosphor-S6 and phosphor-AKT (Ser473), which is consistent with diminished amino acid transportation and metabolism 15

doi: 10.1016/j.pbb.2022.173463

Lewis UJ, Singh RNP, Sinha YN, VanderLaan P