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[DOI] [PubMed] [Google Scholar] 154.Bergles DE, Jahr CE

Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies

Using a Xenopus egg-extract model, which uncouples DNA repair from gene transcription 26 , we determined that IDH1 inhibition increased DSB formation and decreased HR, which was rescued by KG (Fig

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Exogenous copper increases the ubiquitination of GPX4 through direct binding to the cysteine residues C107 and C148 of the GPX4 protein, promoting the formation of GPX4 aggregates