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It is involved in regulating energy metabolism in skeletal muscle and the heart where it is present in relatively high concentrations

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Neuroimaging studies have found that obesity is often associated with decreased serotonin signaling.[8] Other studies note that serotonin administration helps reduce food intake.[9] A systematic review and meta-analysis appearing in The Lancet also state that medications that stimulate serotonin are effective aids for weight reduction.[10] As a direct precursor to serotonin, 5-HTP helps naturally increase serotonin levels

CPT II Type 1 "muscle" phenotype, which is the most frequent clinical presentation, is characterized by recurrent episodes of muscle pain, rhabdomyolysis (a potentially fatal disease that occurs suddenly and with great force destroying skeletal muscle) and myoglobinuria

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