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Similar content being viewed by others Introduction Epilepsy is among the most widespread chronic debilitating neurological disorders, afflicting approximately 70 million people globally, i.e., 12% of worlds population [1, 2]

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In an oxidative ER environment, activated ERO1 generates disulfide bonds by consuming O 2 in the presence of flavin cofactors, which are then passed to the protein for folding via PDI (Wang et al., 2014)

Although the specific mechanisms underlying ferroptosis are not yet clear, and the role of ferroptosis in the pathological process of AD still needs to be investigated, considering the biological regulatory mechanisms of ferroptosis, the pathogenesis of AD, the uniqueness and importance of iron in AD, and the close relationship between ferroptosis and AD, targeting ferroptosis will become a new therapeutic target for AD

Finally, we should expand the field of lung microbiology and diseases research to explore the connection between the lung microbiome and cancer development and metastasis at other sites and to evaluate the value of the lung microbiome more comprehensively

In general terms, stimulated macrophages can be polarized to M1, which are associated with a Th1-type response, or to M2, which are associated with a Th2-type response