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OATP-1 is homogeneously distributed throughout the hepatic acini, while OATP-2 is mainly expressed in perivenous hepatocytes [107,122]

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[43] optimised the enhanced production of ergothioneine (1.85 mg/g d.m in control to 3.45 mg/g d.m) by supplementing two mM methionine as an amino acid precursor in the culture media

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*Reference ranges from Quest Diagnostics, Pediatric Endocrinology

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A recent report also showed that a tricyclic anti-depressant named clomipramine caused mitochondrial dysfunction by decreasing ATP production [319]

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Indeed, SH-SY5Y cells showed high GSH levels but exhibited very low GPx activity, whereas AGS cells had low GSH content but several isoforms of the GPx enzyme

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Wessels I, Pupke JT, von Trotha KT, Gombert A, Himmelsbach A, Fischer HJ, et al

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