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Additionally, two studies examined the effects of maternal nutrition and diet on breast milk composition, but not the effects of supplements on breast milk composition [2, 13]

Another study has shown that ZSS extract can downregulate the levels of NLRP3, GSDMD, ASC, caspase-3, and caspase-8 proteins in the thalamus of CUMS mice, while upregulating the expression of HO1 and NRF2 proteins, thereby alleviating inflammation and oxidative stress (Cheng et al., 2025)

doi: 10.1074/jbc.271.34.20291 128 ShapiraSRaananiPSamaraANaglerALubinIArberNet al

Incorporating studies with negative or null results will help mitigate publication bias and contribute to a more accurate, evidence-based understanding of the role of natural products in AD

That mismatch is the source of most misplaced expectations

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