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The monoamine oxidase inhibitor isocarboxazid is a relevant treatment option in treatment-resistant depression-experience-based strategies in Danish psychiatry

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This approach is supported by many scientific studies, with patients benefiting from completing cognitive therapy immediately after physical exercise

This system regulates extracellular glutamate concentrations through non-vesicular release, establishing a vital feedback loop: the released glutamate activates presynaptic group II metabotropic receptors (mGluR2/3), which in turn inhibit vesicular glutamate release and offer protection against N-methyl-D-aspartate receptor (NMDAR)-mediated excitotoxicity (Figure 2) [8,69,70,71]

doi: 10.1016/j.jsb.2024.108088 [DOI] [PubMed] [Google Scholar] 4.Chen J, Zheng Y, Hu C, Jin X, Chen X, Xiao Y, Wang C

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