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doi: Gorca A, Huk-Kolega H, Piechota A, Kleniewska P, Ciejka E, Skibska B (2011) Lipoic acid-biological activity and therapeutic potential

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The toxic intermediate N-acetyl-p-benzoquinoneimine is formed via which pathway

In science jargon-y terms, the title of my project was Using nanobiopsy and RNA analysis to investigate somatic instability of the CAG repeat in Huntingtons disease induced neurons. One reason we were interested in this was because, although, in general, the longer the inherited CAG tract, the earlier the individual is likely to start experiencing symptoms, there is a wide range of onset ages for patients with a moderate repeat number and one possible reason for this variability is variability in somatic expansion causing different cells to develop longer tracts and form more toxic protein