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Sulfotransferase is available mainly in liver, but can be found in kidney, intestine and other tissues Sulfation Also occur for endogenous compounds, such as steroids, thyroxin, catecholamine and heparin
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Following cellular uptake via endocytosis or phagocytosis, MNPs can disrupt membrane integrity and induce mitochondrial and lysosomal dysfunction, which activate inflammation-related signaling pathways, including NF-B and the NLRP3 inflammasome [31,32]
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