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Therapeutic strategies leveraging this microbiotaBAICI axis are actively under investigation and have shown encouraging results in both preclinical and early clinical settings (62)

While some small trials report modest improvements in lean body mass and metabolic markers, the evidence base is considerably smaller than tesamorelin

P-WS reviewed and approved the manuscript and obtained the funding

Statements Author contributions HMZ: Writing original draft, Writing review & editing

The treatment is regarded as relatively safe, but like any medicine, has potential side effects: Diarrhoea Dizziness Headache Hot flush Nausea Skin reactions Urine discolouration If you are allergic to cobalt please notify your clinician (1-3% of the population have this allergy)

Foundayo (Orforglipron) serves as a daily, easy-to-use, oral option that fits seamlessly into most lifestyles
