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This mtDNA can directly bind to and activate NLRP3, triggering its conformational change and oligomerization [223]

10.1111/j.1365-2125.2012.04425.x Br J Clin Pharmacol

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Cadmium-induced alterations in blood- brain barrier permeability and its possible correlation with decreased microvessel antioxidant potential in rat

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In severe cases, multifocal necrohemorrhagic or malacic areas (up to 1.5 cm in diameter) can be present, especially in the white matter of spinal cord or the white or gray matter of the brain