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Melatonin-induced methylation of the ABCG2/BCRP promoter as a novel mechanism to overcome multidrug resistance in brain tumour stem cells

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Targeted inhibition of NNMT improves insulin responsiveness and may protect against diet-induced obesity. Hong et al., Nature Medicine Longevity and Anti-Aging Potential Because NAD is vital for DNA repair, circadian rhythm regulation, and mitochondrial health, 5-Amino-1MQ is being explored as a geroprotective agent especially when stacked with NAD boosters or sirtuin activators