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Expression of TfR1 was increased, while expression of an iron storage protein complex which includes ferritin heavy chain 1 (FTH1) and ferritin light chain (FTL) was decreased during ferroptosis, indicating the increase in iron uptake and decrease in iron storage during this process ( Numerous efforts have been devoted to clarifying the regulation of iron during ferroptosis
Clinical Nutrition (doi: 10.1016/j.clnu.2006.02.005).
Hence, such gene induction may correlate with various neurological and immune-related symptoms of ME/CFS, as an estimated 38-55% of ME/CFS patients have symptoms that overlap with other autoimmune diseases (501)
Animal studies have found specific probiotics, such as Bacteroides fragilis, can influence behavioral symptoms, though human research is still in early stages
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