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Overall, both increased IGF-1 levels and activated IGF-1R signaling are correlated with PCa progression

doi: 10.3390/ijms21207777 57

Wang D, Zeng Z, Zhang S, Xiong F, He B, Wu Y, et al

[DOI] [PubMed] [Google Scholar] 345.Kurata T, Tamura T, Sasaki Y, Fujii H, Negoro S, Fukuoka M, Saijo N

Extending beyond 16 weeks without a washout period produces diminishing returnsIGF-1 levels stabilize or decline slightly despite continued dosing