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Following GP120 treatment, 100 nM CORT effectively attenuated GP120-induced neuroinflammatory damage in HMC3 cells within 24 hours, whereas the effects of 32 and 320 nM CORT were not significant

Although the APF peptide was found in moderately higher abundance in IC/BPS relative to control urine, our results show that the APF peptide was inconsistently present in urine, suggesting that its utility as a sole biomarker of IC/BPS may be limited

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Furthermore, although beyond the scope of this review, several studies have now established beetroot supplementation as an effective means of enhancing athletic performance [96,97]

Astrocytes release free fatty acids (FFAs) from lipid droplets, and the released fatty acids enter the mitochondria and bind to carnitine to form LCACs, the accumulation of which leads to mitochondrial dysfunction in astrocytes and exacerbates neuronal damage [115]