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Some natural compouds that induce ferroptosis in liver cancer cells are summarized in Table 2

3B), indicating activation of the Nrf2-mediated antioxidant defense pathway

4: Is it proven to reach the target area and deliver therapeutic doses

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( We found that the GPX4 expression and ferrous iron levels were increased in 5-FU- or AZ628-derived tolerant CRC persister cells, which render persister cells sensitive to GPX4 inhibitors-induced ferroptosis

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