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in healthy aging, glucose metabolism is primarily reduced in the frontal cortex, whereas in AD, metabolic deficits are more pronounced in the parietal lobe and precuneus 73
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In addition, IGF2 can bind to InsR-A homodimer (Fig
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Kruger A, Vlok M, Turner S, Venter C, Laubscher GJ, Kell DB, et al
