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(1) they can present tumor-associated antigens (TAA) to the immune system as a vaccine, (2) they can be genetically engineered to deliver exogenous therapeutic genes to be expressed in intratumoral milieu (3) they can also be combined with other immunotherapies like CAR-T cell therapy [44]

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By altering TXNIP expression, increasing SIRT2 activity, and decreasing mitochondrial ROS and dysfunction, silymarin prevents the activation of the NLRP3 inflammasome