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These brain regions were selected since it has been hypothesized that BDZs exert their rewarding properties by interaction with the VTA and NAc, a neural circuit that is a major substrate for motivated behavior, responses to natural rewards and drugs of abuse 71,72

Because it lacks a charge, it can readily diffuse through biological membranes, potentially leading to cellular harm

Mussini, C

Am J Clin Nutr 86(3):661671

Dis., 165:835-845) and the third monkey cyno-83 (FIG

Berberine suppresses amyloid-beta-induced inflammatory response in microglia by inhibiting nuclear factor-kappaB and mitogen-activated protein kinase signalling pathways