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Description
Summary Keywords mRNA therapeutics, mRNA vaccine, mRNA delivery, protein replacement therapy, mRNA design and synthesis, mRNA patents and clinical trials Citation Heendeniya SN, Chen S, Bhatti S, Zahra QUA, Rahimizadeh K, Poudel BH, Wilton SD and Veedu RN (2025) Beginning of a new era of synthetic messenger RNA therapeutics: Comprehensive insights on mRNA drug design, development and applications

Baseline measurements should confirm AMPK suppression (reduced phosphorylation status in muscle or liver) and NAD+ depletion (low tissue NAD+ levels or elevated NNMT enzymatic activity)

Availability of data and materials All data are included in the manuscript

DSIP-

CC performed the primary data analysis, and FV and KR performed secondary data analyses

In terms of achievement of HbA1c target, 81% and 97% of patients treated with tirzepatide reached an HbA1c less than 7%, while 71% and 95% of patients achieved a HbA1c of less than 6.5%
