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The published research trail spans nearly three decades

21 The aforementioned bacteria are recognized for having probiotic activity, which points to the importance of the relationship between vitamin B 12 and the gut microbiota, because probiotics are defined as living microorganisms that provide benefits to the hosts health when administered in adequate doses

Vitamin B 12 deficiency can pose significant adverse effects to organ systems with high cell turnover and metabolism like the bone marrow, gastro-intestinal tract, and brain

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For oral administration, doses typically double (500-1000 mcg) to account for reduced absorption, taken on an empty stomach 30 minutes before meals