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doi: 10.1210/er.2006-0041

Certain individuals are at a higher risk for B12 deficiencyincluding those following strict vegan or vegetarian diets, as well as patients with conditions that impair nutrient absorption, such as pernicious anemia, celiac disease, Crohns disease, or a history of gastrointestinal surgery

Targeting macrophage polarization to modulate the immune response is an appealing therapeutic strategy for autoimmune diseases, cancer, chronic inflammation, and obesity

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21, 23 Consider supplementation when the patient is prescribed medications causing folate deficiency, e.g., methotrexate

Frequency: Once per day (subcutaneous)