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Additionally, the supplementation of dosage and duration of melatonin in infertility and reproductive health needs exploration

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The downstream accumulation of oxidative stress mediated by reactive oxygen species (ROS) from mitochondrial damage, activation of apoptotic pathways, and the disruption of enzymatic and non-enzymatic machinery may facilitate premature follicle activation, follicular apoptosis, and oocyte quality deterioration resulting in the loss of the ovarian reserve and POI

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This is discussed in further detail here by Dr