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Patients with at least a 1 point reduction in pain intensity at the end of a 3-week open-label titration phase were randomized to receive placebo or their optimal fixed dose over 12 weeks

doi: 10.1016/j.bbamcr.2016.01.023 31 MassmigM.ReijerseE.KrauszeJ.LaurichC.LubitzW.JahnD.et al

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observed that CoQ10 facilitates the nuclear localization of Nrf2, enhancing cellular antioxidant defense and mitigating H 2 O 2 -induced neurotoxicity in pheochromocytoma (PC12) cells [91]