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At 24 weeks, the NAC group scored significantly higher than the placebo group on the Bipolar Depression Rating Scale (BDRS) and Montgomery Asberg Depression Rating Scale (MADRS)

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mGSH is also the primary defense against oxidative damage to mitochondrial membranes by ensuring the reduction of hydroperoxide groups on phospholipids and other lipid peroxides through the actions of mitochondrial GSH-S-transferases (GSTs), that exhibit modest Se-independent Gpx activity, and of Gpx4, a membrane-associated enzyme that is partly localized to the intermembrane space of the mitochondria (19, 109, 129)

Acta Neuropathol 125:637650

However, subsequent larger studies failed to replicate these results (Yoritaka et al., 2016)