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185 Pyruvate kinase deficiency has a protective effect against replication of the malarial parasite in human erythrocytes.13,58 This protective effect may be related to reduced ATP levels in PK-deficient red blood cells

(Science-Based Medicine) Potential thyroid, kidney or metabolic disturbances some anecdotal reports and reviews raise these as possible but under-studied risks

The formed chloramines have also been implicated in mediating cytotoxicity to a broad array of microorganisms [223]

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But they remain investigational compounds, and combining them with proper medical care, lifestyle optimization, and realistic timelines produces the most honest and sustainable approach