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Loss-of-function mutations in human KEAP1 have been found in carcinomas of the lung (6973), gallbladder (74), ovary (75), breast (76,77), liver (73) and stomach (73)

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Generally, the FRAP test, as a non-radical SET-based method, was promoted as having a low relation with the process of radical extinction (the HAT mechanism) occurring in lipid systems and has a low correlation with other antioxidant activity measurements

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Furthermore, the protein degradation regulatory system is finely controlled by redox signals, thereby managing the degradation and recycling of damaged or misfolded proteins within cells