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under ROS-related stimulation, the phosphorylation of RelA (p65) modulates NF-B activity, influencing the expression of downstream genes involved in inflammation, immunity, and cell growth
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Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model
Moreover, LET7 TPR and HOP1 stabilize SUMM2 proteins, probably sustaining SUMM2-mediated autoimmunity