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Additionally, practitioners may be hesitant to recommend GHK-Cu formulations without long-term clinical data, slowing adoption in professional settings and limiting market penetration

In addition, Nestin-Cre transgene expression was previously shown to produce a phenotype per se which could have interfered with the responses observed in the present study 40, 41

10.1016/j.stemcr.2017.01.013 [DOI] [PMC free article] [PubMed] [Google Scholar] Takeo S., Takagi N., Takagi K., Date I., Ishida K., Besshoh S., et al

doi: 10.3109/15563650.2013.844822

Both of these cells require glucose as an energy source, leading to a competition between them for glucose uptake in the TME [59,60,61]