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Methionine: This essential amino acid is a precursor to S-adenosylmethionine (SAMe), a universal methyl donor in the body

Mitochondrial biogenesis through activation of nuclear signaling proteins

The cellular mechanisms in MELAS syndrome involve intricate disruptions in mitochondrial function, with a particular focus on impaired oxidative phosphorylation (OXPHOS) and its downstream effects on cellular metabolism

Proc Natl Acad Sci U S A 104:1201712022

Nicoletti F, Bruno V, Ngomba RT, Gradini R, Battaglia G
